GLP-1s and Midlife Metabolism: Dr. Rocio Salas-Whalen Breaks Down the Science of Weight Loss and Menopause: Part 1

Are GLP-1 medications a game-changer for women in midlife—or just another quick fix? In this conversation, triple board-certified endocrinologist Dr. Rocio Salas-Whalen joins Dr. Mary Claire Haver to cut through the hype and share what women really need to know about Ozempic, Wegovy, Mounjaro, and the science behind sustainable weight loss.

Dr. Salas-Whalen, founder of New York Endocrinology and author of the upcoming book Weightless, explains why GLP-1 receptor agonists represent a fundamental shift in how we understand and treat obesity—not as a willpower problem, but as a chronic medical condition with biological drivers including hormones, genetics, and metabolism.

For women navigating perimenopause and menopause, the conversation gets even more specific. Dr. Salas-Whalen breaks down why estrogen decline drives fat redistribution to the abdomen, increases visceral fat, and makes it nearly impossible to lose weight using the same strategies that worked before. She reveals how GLP-1 medications can address the metabolic changes of midlife while protecting what matters most: muscle mass.

Dr. Salas-Whalen shares her clinical experience treating thousands of patients and addresses the viral misinformation circulating online. She explains why obesity is a transgenerational disease influenced by genetics, environment, food accessibility, and even childhood trauma—not personal failure.

Guest links:

Meet Your Endocrinologist - Dr. Salas-Whalen (NY Endocrinology)

Dr. Rocio Salas-Whalen (Instagram)

Books

“Weightless:A Doctor's Guide to GLP-1 Medications, Sustainable Weight Loss, and the Health You Deserve” by Dr. Rocio Salas-Whalen

Articles

• Lossof Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome (Molecular Nutrition and Food Research)

• Increasedvisceral fat and decreased energy expenditure during the menopausal transition (International Journal of Obesity)

• Sex-specific body fat distribution predicts cardiovascular ageing (European Heart Journal)

• Associationbetween metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020(BMC Public Health)

• Thediscovery and development of GLP-1 based drugs that have revolutionized the treatment of obesity (PNAS)

• Skeletal Muscle as Endocrine Organ (Advances in Experimental Medicine and Biology)

• PreservingHealthy Muscle during Weight Loss (Advances in Nutrition)

• 32ndEuropean Congress on Obesity (ECO 2025)(S. Karger AG, Basel)

• Associationof Obesity With COVID-19 Severity and Mortality: An Updated Systemic Review, Meta-Analysis, and Meta-Regression (Frontiers in Endocrinology)

• Adverse Events Related to Tirzepatide (Journal of the Endocrine Society)

• Weightloss response to semaglutide in postmenopausal women with and without hormone therapy use (Menopause)

• Clinicaldevelopment times for innovative drugs (Nature Reviews Drug Discovery)

• Thedual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide: a novel cardiometabolic therapeutic prospect (Cardiovascular Diabetology)

• Dose-dependent pancreatitis risk associated with GLP-1 agonists (Journal of Diabetes and Metabolic Disorders)

• Mortalityfrom type 2 diabetes mellitus across municipalities in Mexico (Arch Public Health)

• Theassociation between age of menopause and type 2 diabetes: a systematic review and meta-analysis (Nutrition & Metabolism)

• Obesityin Infertile Women, a Cross-Sectional Study of the United States Using NSFG 2011-2019(Reproductive Sciences)

BisphenolA and the Risk of Obesity a Systematic Review With Meta-Analysis of the Epidemiological Evidence (Dose-Response)

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