The Peter Attia Drive
Peter Attia, MD - PeterAttiaMD.com
Latest episode: Mon Mar 17 2025
Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.
386 total episodes
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- Mar17#340 - AMA #69: Scrutinizing supplements: creatine, fish oil, vitamin D, and more—a framework for understanding effectiveness, quality, and individual need24mins
- Mar10#339 - Unpacking trauma: How early wounds shape behavior and the path toward healing | Jeff English122mins
- Mar3#338 ‒ Peter’s takeaways on aerobic exercise and VO2 max, insulin resistance, rising healthcare costs, treating children with autism and ADHD, and strength training | Quarterly Podcast Summary #427mins
- Feb24#337 - Insulin resistance masterclass: The full body impact of metabolic dysfunction and prevention, diagnosis, and treatment | Ralph DeFronzo, M.D.146mins
- Feb17#336 - AMA #68: Fasting, well-balanced diets, alcohol, exercise for busy people, wearables, emotional health, assessing cardiovascular health, and more27mins
- Feb10#335 ‒ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.171mins
- Feb3#334 - Cardiovascular disease, the number one killer: development, biomarkers, apoB, cholesterol, brain health, and more | Tom Dayspring, M.D.137mins
- Jan27#333 ‒ Longevity roundtable — the science of aging, geroprotective molecules, lifestyle interventions, challenges in research, and more | Steven Austad, Matt Kaeberlein, Richard Miller161mins
- Jan20#332 - AMA #67: Microplastics, PFAS, and phthalates: understanding health risks and a framework for minimizing exposure and mitigating risk25mins
- Jan13#331 ‒ Optimizing endurance performance: metrics, nutrition, lactate, and more insights from elite performers | Olav Aleksander Bu (Pt. 2)136mins
- Jan6#330 – Autism, ADHD, and Anxiety: Understanding the rise in autism and a multidisciplinary approach to diagnosis and treatment of each condition in children | Trenna Sutcliffe, M.D.117mins
- Dec30Building & Changing Habits | James Clear (#183 rebroadcast)139mins
- Dec16#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more27mins
- Dec9#328 - AMA #66: Optimizing nutrition for health and longevity: myth of a “best” diet, complexities of nutrition science, and practical steps for building a sustainable diet16mins
- Dec2#327 - Choices, costs, and challenges in US healthcare: insurance intricacies, drug pricing, economic impacts, and potential reforms | Saum Sutaria, M.D.152mins
- Nov25Optimizing life for maximum fulfillment | Bill Perkins (#237 rebroadcast)103mins
- Nov18#326 - AMA #65: Red light therapy: promising applications, mixed evidence, and impact on health and aging15mins
- Nov11#325 ‒ Peter’s key takeaways on bone health, calorie restriction and energy balance, dopamine and addiction, gene editing, and testosterone therapy safety with a prostate cancer diagnosis | Quarterly Podcast Summary #325mins
- Nov4#324 ‒ Metabolism, energy balance, and aging: How diet, calorie restriction, and macronutrients influence longevity and metabolic health | Eric Ravussin, Ph.D.129mins
- Oct28#323 - CRISPR and the future of gene editing: scientific advances, genetic therapies, disease treatment potential, and ethical considerations | Feng Zhang, Ph.D.125mins
- Oct21#322 - Bone health for life: building strong bones, preventing age-related loss, and reversing osteoporosis with evidence-based exercise | Belinda Beck, Ph.D.99mins
- Oct14#321 – Dopamine and addiction: navigating pleasure, pain, and the path to recovery | Anna Lembke, M.D.141mins
- Oct7#320 – AMA 64: New insights on GLP-1 agonists (Ozempic, Wegovy, Mounjaro) - efficacy, benefits, risks, and considerations in the rapidly evolving weight-loss drug landscape20mins
- Sep30#319 ‒ Peter's key takeaways on liver health, heart rate variability, AI in medicine, klotho, and lactate metabolism | Quarterly Podcast Summary #228mins
- Sep23#318 ‒ Cycling phenom and Tour de France champion Tadej Pogačar reveals his training strategies, on-bike nutrition, and future aspirations45mins
- Sep16#317 ‒ Reforming medicine: uncovering blind spots, challenging the norm, and embracing innovation | Marty Makary, M.D., M.P.H.123mins
- Sep9#316 - AMA #63: A guide for hair loss: causes, treatments, transplants, and sex-specific considerations20mins
- Sep2Improve your decision-making, frameworks for learning, backcasting, and more | Annie Duke (#60 rebroadcast)152mins
- Aug26#315 ‒ Life after near-death: a new perspective on living, dying, and the afterlife | Sebastian Junger123mins
- Aug19#314 ‒ Rethinking nutrition science: the evolving landscape of obesity treatment, GLP-1 agonists, protein, and the need for higher research standards | David Allison, Ph.D.118mins
- Aug12#313 - AMA #62: Protein’s impact on appetite and weight management, and uric acid's link to disease and how to manage levels24mins
- Aug5#312 - A masterclass in lactate: Its critical role as metabolic fuel, implications for diseases, and therapeutic potential from cancer to brain health and beyond | George A. Brooks, Ph.D.126mins
- Jul29#311 ‒ Longevity 101: a foundational guide to Peter's frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more85mins
- Jul22#310 - The relationship between testosterone and prostate cancer, testosterone replacement therapy, and tools for predicting cancer aggressiveness and guiding therapy | Ted Schaeffer, M.D., Ph.D.47mins
- Jul15#309 ‒ AI in medicine: its potential to revolutionize disease prediction, diagnosis, and outcomes, causes for concern in medicine and beyond, and more | Isaac Kohane, M.D., Ph.D.115mins
- Jul8Zone 2 training: impact on longevity and mitochondrial function, how to dose frequency and duration, and more | Iñigo San-Millán, Ph.D. (#201 rebroadcast)166mins
- Jul1#308 - AMA #61: Sun exposure, sunscreen, and skin health: relationship between sun exposure and skin cancer, vitamin D production, and photoaging, how to choose a sunscreen, and more22mins
- Jun24#307 ‒ Exercise for aging people: where to begin, and how to minimize risk while maximizing potential | Peter Attia, M.D.99mins
- Jun17#306 - AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more18mins
- Jun10#305 ‒ Heart rate variability: how to measure, interpret, and utilize HRV for training and health optimization | Joel Jamieson111mins
- Jun3#304 – NEW: Introducing quarterly podcast summaries - Peter shares his biggest takeaways on muscle protein synthesis, VO2 max, toe strength, gut health, and more30mins
- May27#303 - A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer's disease | Dena Dubal, M.D., Ph.D.125mins
- May20#302 - Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage liver disease | Julia Wattacheril, M.D., M.P.H.145mins
- May13#301 - AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it24mins
- May6#300 - Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?100mins
- Apr29Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna’s death148mins
- Apr22#299 ‒ Optimizing muscle protein synthesis: the crucial impact of protein quality and quantity, and the key role of resistance training | Luc van Loon, Ph.D.150mins
- Apr15#298 ‒ The impact of emotional health on longevity, self-audit strategies, improving well-being, and more | Paul Conti, M.D.143mins
- Apr8#297 - AMA #58: Iron: its role in health, testing methods, and strategies for preventing and managing iron deficiency17mins
- Apr1#296 ‒ Foot health: preventing and treating common injuries, enhancing strength and mobility, picking footwear, and more | Courtney Conley, D.C.142mins
- Mar25#295 ‒ Roadway death and injury: why everyone should care and what you can do to reduce risk | Mark Rosekind, Ph.D.149mins
- Mar18#294 ‒ Peak athletic performance: How to measure it and how to train for it from the coach of the most elite athletes on earth | Olav Aleksander Bu153mins
- Mar11#293 - AMA #57: High-intensity interval training: benefits, risks, protocols, and impact on longevity18mins
- Mar4#292 ‒ Rucking: benefits, gear, FAQs, and the journey from Special Forces to founding GORUCK | Jason McCarthy150mins
- Feb26#291 ‒ The role of testosterone in males and females, performance-enhancing drugs, sustainable fat loss, supplements, and more | Derek, More Plates More Dates Pt.2158mins
- Feb19#290 ‒ Liquid biopsies for early cancer detection, the role of epigenetics in aging, and the future of aging research | Alex Aravanis, M.D., Ph.D.125mins
- Feb12#289 - AMA #56: Cancer screening: pros and cons, screening options, interpreting results, and more20mins
- Feb5#288 ‒ The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green92mins
- Jan29#287 ‒ Lower back pain: causes, treatment, and prevention of lower back injuries and pain | Stuart McGill, Ph.D.155mins
- Jan22#286 ‒ Journal club with Andrew Huberman: the impact of light exposure on mental health and an immunotherapy breakthrough for cancer treatment166mins
- Jan15#285 - AMA #55: Exercise: longevity-focused training, goal setting, improving deficiencies, managing emotional stress, and more21mins
- Jan8#284 ‒ Overcoming addictive behaviors, elevating wellbeing, thriving in an era of excess, and the scarcity loop | Michael Easter, M.A.117mins
- Jan1James Clear: Building & Changing Habits (#183 rebroadcast)139mins
- Dec18#283 ‒ Gut health & the microbiome: improving and maintaining the microbiome, probiotics, prebiotics, innovative treatments, and more | Colleen Cutcliffe, Ph.D.152mins
- Dec11#282 - AMA #54: Magnesium: risks of deficiency, how to correct it, supplement options, potential cognitive and sleep benefits, and more20mins
- Dec4#281 ‒ Longevity drugs, aging biomarkers, and updated findings from the Interventions Testing Program (ITP) | Rich Miller, M.D., Ph.D.143mins
- Nov27#280 ‒ Cultivating happiness, emotional self-management, and more | Arthur Brooks Ph.D.120mins
- Nov20The world’s most important doctor to millions in the war-torn and remote villages of Sudan | Tom Catena, M.D. (#40 rebroadcast)159mins
- Nov13#279 - AMA #53: Metabolic health & pharmacologic interventions: SGLT-2 inhibitors, metformin, GLP-1 agonists, and the impact of statins27mins
- Nov6#278 ‒ Breast cancer: how to catch, treat, and survive breast cancer | Harold Burstein, M.D., Ph.D.130mins
- Oct30#277 ‒ Food allergies: causes, prevention, and treatment with immunotherapy | Kari Nadeau, M.D., Ph.D.105mins
- Oct23#276 ‒ Special episode: Peter answers questions on longevity, supplements, protein, fasting, apoB, statins, and more79mins
- Oct16#275 - AMA #52: Hormone replacement therapy: practical applications and the role of compounding pharmacies18mins
- Oct9#274 - Performance-enhancing drugs and hormones: risks, rewards, and broader implications for the public | Derek: More Plates, More Dates194mins
- Oct2#273 ‒ Prostate health: common problems, cancer prevention, screening, treatment, and more | Ted Schaeffer, M.D., Ph.D.209mins
- Sep25#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.170mins
- Sep18#271 - AMA #51: Understanding and improving your metabolic health19mins
- Sep11#270 ‒ Journal club with Andrew Huberman: metformin as a geroprotective drug, the power of belief, and how to read scientific papers136mins
- Sep4#269 - Good vs. bad science: how to read and understand scientific studies110mins
- Aug28#268 ‒ Genetics: testing, therapy, editing, association with disease risk, autism, and more | Wendy Chung, M.D., Ph.D.147mins
- Aug21#267 ‒ The latest in cancer therapeutics, diagnostics, and early detection | Keith Flaherty, M.D.110mins
- Aug14#266 - AMA #50: Genetics: how they impact disease risk, what you can do about it, testing, and more26mins
- Aug7#265 - Time, productivity, and purpose: insights from Four Thousand Weeks | Oliver Burkeman110mins
- Jul31#264 ‒ Hip, knee, ankle, and foot: common injuries, prevention, and treatment options129mins
- Jul24#263 ‒ Concussions and head trauma: symptoms, treatment, and recovery | Micky Collins, Ph.D.81mins
- Jul17#262 - AMA #49: Heart rate recovery, strength training, rucking, kidney function, and brain health20mins
- Jul10#261 ‒ Training for The Centenarian Decathlon: zone 2, VO2 max, stability, and strength | Peter Attia, M.D.64mins
- Jul3Cancer screening with full-body MRI scans and a seminar on the field of radiology | Rajpaul Attariwala, M.D., Ph.D. (#61 rebroadcast)129mins
- Jun26#260 ‒ Men’s Sexual Health: why it matters, what can go wrong, and how to fix it | Mohit Khera, M.D., M.B.A., M.P.H.153mins
- Jun19#259 - Women's sexual health: Why it matters, what can go wrong, and how to fix it | Sharon Parish, M.D.168mins
- Jun12#258 - AMA #48: Blood pressure—how to measure, manage, and treat high blood pressure26mins
- Jun5#257 ‒ Cognitive decline, neurodegeneration, and head injuries: mitigation and prevention strategies, supplements, and more | Tommy Wood, M.D., Ph.D.127mins
- May29#256 ‒ The endocrine system: exploring thyroid, adrenal, and sex hormones | Peter Attia, M.D.57mins
- May22#255 ‒ Latest therapeutics in CVD, APOE’s role in Alzheimer’s disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.124mins
- May15#254 - AMA #47: Cold therapy: pros, cons, and its impact on longevity14mins
- May8#253 ‒ Hormone replacement therapy and the Women’s Health Initiative: re-examining the results, the link to breast cancer, and weighing the risk vs reward of HRT | JoAnn Manson, M.D.80mins
- May1#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.149mins
- Apr24The impact of stress on our physical and emotional health | Robert Sapolsky, Ph.D. (#51 rebroadcast)135mins
- Apr17#251 - AMA #46: Optimizing brain health: Alzheimer's disease risk factors, APOE, prevention strategies, and more34mins
- Apr10#250 ‒ Training principles for longevity | Andy Galpin, Ph.D. (PART II)166mins
- Apr3#249 ‒ How the brain works, Andrew’s fascinating backstory, improving scientific literacy, and more | Andrew Huberman, Ph.D.170mins
- Mar28#248 ‒ OUTLIVE book: A behind-the-scenes look into the writing of this book, motivation, main themes, and more101mins
- Mar20#247 ‒ Preventing cardiovascular disease: the latest in diagnostic imaging, blood pressure, metabolic health, and more | Ethan Weiss, M.D.132mins
- Mar13#246 - AMA #45: Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent27mins
- Mar6#245 ‒ Overcoming trauma, finding inner peace, and living a meaningful and fulfilling life | Lewis Howes94mins
- Feb27#244 ‒ The history of the cell, cell therapy, gene therapy, and more | Siddhartha Mukherjee100mins
- Feb20#243 ‒ The fentanyl crisis and why everyone should be paying attention | Anthony Hipolito66mins
- Feb13#242 - AMA #44: Peter’s historical changes in body composition with his evolving dietary, fasting, and training protocols24mins
- Feb6#241 ‒ Living intentionally, valuing time, prioritizing relationships, and more keys to a rich life | Ric Elias (Part 2)82mins
- Jan30#240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.114mins
- Jan23#239 ‒ The science of strength, muscle, and training for longevity | Andy Galpin, Ph.D. (PART I)155mins
- Jan16#238 – AMA #43: Understanding apoB, LDL-C, Lp(a), and insulin as risk factors for cardiovascular disease24mins
- Jan9#237 ‒ Optimizing life for maximum fulfillment | Bill Perkins103mins
- Dec26James Clear: Building & Changing Habits (#183 rebroadcast)139mins
- Dec19#235 ‒ Training principles for mass and strength, changing views on nutrition, creatine supplementation, and more | Layne Norton, Ph.D.168mins
- Dec12#234 ‒ Chris Hemsworth on Limitless, longevity, and happiness71mins
- Dec5#233 - AMA #42: Optimizing sleep - bedtime routine, molecule regimen, sleep trackers, sauna, & more23mins
- Nov28#232 ‒ Shoulder, elbow, wrist, and hand: diagnosis, treatment, and surgery of the upper extremities | Alton Barron, M.D.218mins
- Nov21A masterclass on insulin resistance—mechanisms and implications | Gerald Shulman, M.D., Ph.D. (#140 rebroadcast)126mins
- Nov14#231 - AMA #41: Medicine 3.0, developments in the field of aging, healthy habits in times of stress, and more16mins
- Nov7#230 ‒ Cardiovascular disease in women: prevention, risk factors, lipids, and more | Erin Michos, M.D.135mins
- Oct31#229 ‒ Understanding cardiovascular disease risk, cholesterol, and apoB78mins
- Oct24#228 ‒ Improving body composition, female-specific training principles, and overcoming an eating disorder | Holly Baxter, APD135mins
- Oct17#227 - AMA #40: Body composition, protein, time-restricted feeding, fasting, DEXA scans, and more16mins
- Oct10#226 ‒ The science of happiness | Arthur Brooks, Ph.D.100mins
- Oct3#225 ‒ The comfort crisis, doing hard things, rucking, and more | Michael Easter, MA108mins
- Sep26#224 ‒ Dietary protein: amount needed, ideal timing, quality, and more | Don Layman, Ph.D.122mins
- Sep19#223 - AMA #39: The Centenarian Decathlon, zone 2, VO2 max, and more16mins
- Sep12#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D147mins
- Sep5#221 ‒ Understanding sleep and how to improve it97mins
- Aug29#220 ‒ Ketamine: Benefits, risks, and promising therapeutic potential | Celia Morgan, Ph.D.87mins
- Aug22#219 ‒ Dialectical behavior therapy (DBT): skills for overcoming depression , emotional dysregulation, and more | Shireen Rizvi, Ph.D., ABPP136mins
- Aug15#218 - AMA #38: Can you exercise too much?17mins
- Aug8#217 ‒ Exercise, VO2 max, and longevity | Mike Joyner, M.D.112mins
- Aug1#216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.131mins
- Jul25#215 - The gut-brain connection | Michael Gershon, M.D.132mins
- Jul18#214 - AMA #37: Bone health—everything you need to know17mins
- Jul11#213 ‒ Liquid biopsies and cancer detection | Max Diehn, M.D. Ph.D.126mins
- Jul4Earning the gift of life | Ric Elias (#79 rebroadcast)99mins
- Jun27#212 - The neuroscience of obesity | Stephan Guyenet, Ph.D.144mins
- Jun20#211 - AMA #36: Fruits & vegetables—everything you need to know20mins
- Jun13#210 - Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.127mins
- Jun6#209 ‒ Medical mistakes, patient safety, and the RaDonda Vaught case | Marty Makary, M.D., M.P.H.105mins
- May23#208 - Tragedy, grief, healing, and finding happiness | Kelsey Chittick114mins
- May16#207 - AMA #35: "Anti-Aging" Drugs — NAD+, metformin, & rapamycin30mins
- May9#206 - Exercising for longevity: strength, stability, zone 2, zone 5, and more74mins
- May2#205 - Energy balance, nutrition, & building muscle | Layne Norton, Ph.D. (Pt.2)175mins
- Apr25#204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.149mins
- Apr18#203 - AMA #34: What Causes Heart Disease?16mins
- Apr11#202 - Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes117mins
- Apr4In remembrance of Sarah Hallberg, D.O., M.S. (Ep. #162 Rebroadcast)137mins
- Mar28#201 - Deep dive back into Zone 2 | Iñigo San-Millán, Ph.D. (Pt. 2)165mins
- Mar21#200 - AMA #33: Hydration—electrolytes, supplements, sports drinks, performance effects, and more19mins
- Mar14#199 - Running, overcoming challenges, and finding success | Ryan Hall175mins
- Mar7#198 - Eye health—everything you need to know | Steven Dell, M.D.163mins
- Feb28#197 - The science of obesity & how to improve nutritional epidemiology | David Allison, Ph.D.134mins
- Feb21#196 - AMA #32: Exercise, squats, deadlifts, BFR, and TRT19mins
- Feb14#195 - Freedom, PTSD, war, and life through an evolutionary lens | Sebastian Junger177mins
- Feb7#194 - How fructose drives metabolic disease | Rick Johnson, M.D.125mins
- Jan31#193 - AMA #31: Heart rate variability (HRV), alcohol, sleep, and more13mins
- Jan24#192 - COVID Part 2: Masks, long COVID, boosters, mandates, treatments, and more172mins
- Jan17#191 - Revolutionizing our understanding of mental illness with optogenetics | Karl Deisseroth M.D., Ph.D.149mins
- Jan10#190 - Paul Conti, M.D.: How to heal from trauma and break the cycle of shame140mins
- Jan3#189 - COVID-19: Current state of affairs, Omicron, and a search for the end game165mins
- Dec27Iñigo San Millán, Ph.D.: Zone 2 Training and Metabolic Health (Ep. #85 Rebroadcast)170mins
- Dec20#188 - AMA #30: How to Read and Understand Scientific Studies30mins
- Dec13#187 - Sam Apple: The Warburg Effect—Otto Warburg’s cancer metabolism theory108mins
- Dec6#186 - Patrick Radden Keefe: The opioid crisis—origin, guilty parties, and the difficult path forward115mins
- Nov29#185 - Allan Sniderman, M.D.: Cardiovascular disease and why we should change the way we assess risk122mins
- Nov22Rick Johnson, M.D.: Metabolic Effects of Fructose (Ep. #87 Rebroadcast)109mins
- Nov15#184 - AMA #29: GLP-1 Agonists—The Future of Treating Obesity?14mins
- Nov8#183 - James Clear: Building & changing habits138mins
- Nov1#182 - David Nutt: Psychedelics & Recreational Drugs98mins
- Oct25#181 - Robert Gatenby, M.D.: Viewing cancer through an evolutionary lens and why this offers a radically different approach to treatment119mins
- Oct18#180 - AMA #28: All things testosterone and testosterone replacement therapy20mins
- Oct11#179 - Jeremy Loenneke, Ph.D.: The science of blood flow restriction—benefits, uses, and what it teaches us about the relationship between muscle size and strength119mins
- Oct4#178 - Lance Armstrong: The rise, fall, and growth of a cycling legend118mins
- Sep27#177 - Steven Rosenberg, M.D., Ph.D.: The development of cancer immunotherapy and its promise for treating advanced cancers126mins
- Sep20#176 - AMA #27: The importance of muscle mass, strength, and cardiorespiratory fitness for longevity18mins
- Sep13#175 - Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process160mins
- Sep6#174 - Lawrence Wright: The 20th anniversary of the 9/11 attacks: reflections on how they happened, and lessons learned and not learned181mins
- Aug23#173 - AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions19mins
- Aug16#172 - Esther Perel: The effects of trauma, the role of narratives in shaping our worldview, and why we need to accept uncomfortable emotions124mins
- Aug9#171 - Steve Austad, Ph.D.: The landscape of longevity science: making sense of caloric restriction, biomarkers of aging, and possible geroprotective molecules146mins
- Jul26#170 - AMA #25: Navigating the complexities and nuances of cancer screening12mins
- Jul19#169 - Katherine Eban: COVID-19 Lab Leak: Examining all sides of the debate and discussing barriers to a full investigation99mins
- Jul12#168 - Hugh Jackman: Reflections on acting, identity, personal transformation, and the significance of being Wolverine129mins
- Jun28#167 - Gary Taubes: Bad science and challenging the conventional wisdom of obesity156mins
- Jun21#166 - Patricia Corby, D.D.S.: Importance of oral health, best hygiene practices, and the relationship between poor oral health and systemic disease120mins
- Jun14#165 - AMA #24: Deep dive into blood glucose: why it matters, important metrics to track, and superior insights from a CGM17mins
- Jun7#164 - Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer’s disease, and what we can all learn from patients with dementia121mins
- May24#163 - Layne Norton, Ph.D.: Building muscle, losing fat, and the importance of resistance training161mins
- May17#162 - Sarah Hallberg, D.O., M.S.: Challenging the status quo of treating metabolic disease, and a personal journey through a grim cancer diagnosis141mins
- May10#161 - AMA #23: All Things Nicotine: deep dive into its cognitive and physical benefits, risks, and mechanisms of action19mins
- May3#160 - Paul Offit, M.D.: The latest on COVID-19 vaccines and their safety, herd immunity, and viral variants85mins
- Apr26#159 - Peter Hotez, M.D., Ph.D.: Evolution of the anti-vaccine movement, the causes of autism, and COVID-19 vaccine state of affairs114mins
- Apr19#158 - Brian Deer: A tale of scientific fraud—exposing Andrew Wakefield and the origin of the belief that vaccines cause autism109mins
- Apr12#157 - AMA #22: Losing fat and gaining fat: the lessons of fat flux15mins
- Apr5#156 - Jake Muise: Humanely harvesting axis deer while alleviating its impact on Hawaii’s vulnerable ecosystems139mins
- Mar29#155 - Chris Sonnenday, M.D.: The history, challenges, and gift of organ transplantation134mins
- Mar22#154 - Steve Levitt, Ph.D.: A rogue economist’s view on climate change, mental health, the ethics of experiments, and more120mins
- Mar15#153 - AMA #21: Deep dive into olive oil, high-intensity exercise, book update, and more14mins
- Mar8#152 - Michael Rintala, D.C.: Principles of Dynamic Neuromuscular Stabilization (DNS)95mins
- Mar1#151 - Alex Hutchinson, Ph.D.: Translating the science of endurance and extreme human performance133mins
- Feb22#150 - Senator Bill Frist, M.D.: A modern Renaissance man's journey through science, politics, and business143mins
- Feb15#149 - AMA #20: Simplifying the complexities of insulin resistance: how it's measured, how it manifests in the muscle and liver, and what we can do about it23mins
- Feb8#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program134mins
- Feb1#147 - Hussein Yassine, M.D.: Deep dive into the “Alzheimer’s gene” (APOE), brain health, and omega-3s126mins
- Jan25#146 - Guy Winch, Ph.D.: Emotional first aid and how to treat psychological injuries117mins
- Jan18#145 - AMA #19: Deep dive on Zone 2 training, magnesium supplementation, and how to engage with your doctor17mins
- Jan11#144 - Phil Maffetone: Optimizing health and performance through maximal aerobic function82mins
- Jan4#143 - John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it112mins
- Dec21#142 - Robert Abbott: The Bobby Knight story—a cautionary tale of unchecked anger, ego, and winning at all costs134mins
- Dec14#141 - AMA #18: Deep dive: sugar and sugar substitutes16mins
- Dec7#140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications128mins
- Nov30#139 - Kristin Neff, Ph.D.: The power of self-compassion76mins
- Nov23#138 - Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives131mins
- Nov16#137 - Paul Offit, M.D.: An expert perspective on COVID-19 vaccines95mins
- Nov9#136 - AMA #17: Body composition methods tour de force, insulin resistance, and Topo Chico18mins
Nov2#135 - BJ Miller, M.D.: How understanding death leads to a better life114mins
Oct26#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise.129mins
Oct19#133 - Vinay Prasad, M.D., M.P.H: Hallmarks of successful cancer policy132mins- Oct12#132 - AMA #16: Exploring hot and cold therapy19mins
Sep28#130 - Carol Tavris, Ph.D. & Elliot Aronson, Ph.D.: Recognizing and overcoming cognitive dissonance119mins
Sep21#129 - Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology120mins
Sep14#128 – Irene Davis, Ph.D.: The evolution of the foot, running injuries, and minimalist shoes113mins- Sep7#127 - AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and more15mins
Aug31#126 – Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his book101mins
Aug24#125 - John Arnold: The most prolific philanthropist you may not have heard of148mins- Aug17#124 - AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more16mins
Aug10#123 - Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19137mins
Aug3#122 - Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health90mins
Jul27#121 - Azra Raza, M.D.: Why we're losing the war on cancer114mins- Jul20#120 - AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health28mins
Jul13#119 - Terry Real: Breaking the cycle of shame, anger, and depression99mins
Jul6#118 - Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging134mins
Jun29#117 - Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19103mins- Jun22#116 - AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise28mins
Jun15#115 - David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-1997mins
Jun8#114 - Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies118mins- Jun3#113: Normative errors—a conversation with my daughter about current events22mins
Jun1#112 - Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it135mins- May18#111 - AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity17mins
May11#110 - Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K131mins
May4#109 - John Dudley: The beauty in archery, the love of practice, and a model system for life136mins
Apr21#108 - AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity15mins- Apr17#107 - John Barry: 1918 Spanish flu pandemic—historical account, parallels to today, and lessons81mins
Apr13#106 - Amesh Adalja, M.D.: Comparing COVID-19 to past pandemics, preparing for the future, and reasons for optimism44mins- Apr10#105 - Paul Conti, M.D.: The psychological toll of a pandemic, and the societal problems it has highlighted86mins
Apr8#104 - COVID-19 for kids with Olivia Attia34mins
Apr6#103 - Looking back on the first 99 episodes: Strong Convictions, Loosely Held77mins- Mar31#102 - Michael Osterholm, Ph.D.: COVID-19—Lessons learned, challenges ahead, and reasons for optimism and concern82mins
- Mar27#101 - Ryan Holiday: Finding stillness amidst chaos82mins
- Mar24#100 - Sam Harris, Ph.D.: COVID-19—Comprehending the crisis and managing our emotions92mins
- Mar20#99 - Peter Hotez, M.D., Ph.D.: Continuing the conversation on COVID-1966mins
- Mar17Qualy #129 - Evolutionary reasons to sleep9mins
- Mar14#97 - Peter Hotez, M.D., Ph.D.: COVID-19: transmissibility, vaccines, risk reduction, and treatment57mins
- Mar10Qualy #125 - Hierarchies in healthcare, physician burnout, and a broken system13mins
Mar9#96 - David Epstein: How a range of experience leads to better performance in a highly specialized world157mins- Mar3Qualy #121 - The “art” of longevity: the challenge of preventative medicine and understanding risk10mins
Mar2#95 - Luke Bennett, M.D.: The emotional, cognitive, and physical demands that make Formula 1 a unique and special sport98mins- Feb28Qualy #120 - What is the difference between ketone salts and esters?6mins
Feb24#94 - Mark Hyman, M.D.: The impact of the food system on our health and the environment110mins- Feb21Qualy #116 - Dealing with anger in spots where you know it’s coming8mins
Feb17#93 - AMA with Jason Fried: Work-life balance, avoiding burnout, defining success, company culture, and more127mins- Feb11Qualy #109 - How does one select the right physician as a patient?9mins
Feb1092 - AMA #12: Strategies for longevity (which don't require a doctor)15mins- Feb5Qualy #106 - Does LDL cause heart disease?9mins
Feb3#91 – Eric Topol, M.D.: Can AI empower physicians and revolutionize patient care?121mins- Jan29Qualy #102 - Is the food industry still saying that all calories contribute equally to adiposity and insulin resistance?7mins
Jan27#90 - Ryan Holiday: Stillness, stoicism, and suffering less136mins- Jan23Qualy #99 - The steroid controversy: Mark’s use of them and Peter’s perspective11mins
- Jan20#89 - AMA #11: All things fasting14mins
- Jan15Qualy #94 - Comparing the two broad types of meditation, and Peter’s favorite meditation apps7mins
- Jan7Qualy #89 - Cortisol and healthy aging9mins
Jan6#87 - Rick Johnson, M.D.: Fructose—The common link in high blood pressure, insulin resistance, T2D, & obesity?110mins- Dec31Qualy #85 - The past, present, and future of medicine, hospitals, and healthcare13mins
Dec30#86 - Damon Hill: Overcoming loss, achieving success, and finding one's identity147mins- Dec25Qualy #82 - What is the most common first presentation of heart disease?7mins
Dec23#85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health173mins- Dec20Qualy #80 - The four pillars of charity: water that helped it overcome the stigma of nonprofits and become successful11mins
Dec16#84 - AMA #10: Low testosterone, hypothyroidism, building muscle (and preserving it while fasting)10mins- Dec10Qualy #73 - How can we change the food system when 10 companies control almost 90 percent of the calories we consume in the US?8mins
Dec9#83 - Bill Harris, Ph.D.: Omega-3 fatty acids122mins- Dec3Qualy #69 - Advice to parents and kids for creating a sustainable environment that’s going to prevent them from running into metabolic problems9mins
Dec2#82 - Mark Messier: Leadership, personal growth, and performing under pressure130mins
Nov26Qualy #65 - The three laws of medicine — Law #1: A strong intuition is much more powerful than a weak test6mins
Nov25#81 - Debra Kimless, M.D. & Steve Goldner, J.D.: Cannabis – the latest science on CBD & THC131mins
Nov19Qualy #61 - Rapamycin in cancer treatment10mins
Nov18#80 - Celebrity AMA #1: Fasting, rapamycin, performance vs. longevity, and more12mins
Nov12Qualy #57 - A primer on NAD+/NADH, its effect on lifespan/healthspan, and a review of the supplements8mins
Nov11#79 - Ric Elias: Earning the gift of life101mins- Nov5Qualy #53 - Screening for prostate cancer16mins
Nov4#78 - Sasha Cohen: The price of achievement, and redefining success133mins
Nov1Qualy #52 - Insights about berberine5mins
Oct28#77 – AMA #2 with sleep expert, Matthew Walker, Ph.D.: short sleep mutants, optimal sleep environment, sleep apnea, & rapid fire questions29mins
Oct23Qualy #46 - Rapamycin’s effects on cancer, cardiovascular disease, and neurodegeneration8mins
Oct21#76 - Kyle Kingsbury: Finding meaning, depression, and psychedelics101mins
Oct17Qualy #43 - What are Peter’s thoughts on fasting and ketosis for females?8mins
Oct14#75 - David Light: Zantac recall due to cancer concerns – what you need to know97mins
Oct9Qualy #38 - Finding meaning in struggle and why we are less happy than ever (David Foster Wallace)7mins
Oct7#74 – Jason Fried: Optimizing efficiency and work-life balance144mins
Oct1Qualy #33 - How silent bravado and incessant striving can lead to a functional (and actual) death, and why Paul is critical of the current state of psychiatry9mins
Sep30#73 - AMA #9: NAD & metformin, fat-burning zone, creatine, estrogenization of men, emergency kit for cold & flu, and more16mins
Sep23#72 - Dan Harris: 10% happier – meditation, kindness, and compassion144mins
Sep18Qualy #26 - What is Peter looking to achieve and monitor with his blood glucose monitor?12mins
Sep16#71 - Katherine Eban: Widespread fraud in the generic drug industry161mins
Sep13Qualy #24 - What are the “ABCs” of Alzheimer’s prevention?11mins
Sep9#70 - David Sinclair, Ph.D.: How cellular reprogramming could slow our aging clock (and the latest research on NAD)130mins
Sep5Qualy #19 - A unifying theory of aging10mins
Sep2#69 - Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease in a patient population predisposed to metabolic syndrome, and what it teaches us more broadly119mins
Aug30Qualy #16 - How much does cognitive activity ward off cognitive decline?7mins
Aug26#68 - Marty Makary, M.D.: The US healthcare system—why it’s broken, steps to fix it, and how to protect yourself169mins
Aug20Qualy #9 - The importance of exercise for brain health9mins
Aug19#67 - AMA #8: DNA tests, longevity genes, metformin, fasting markers, salt, inflammation, and more18mins
Aug14Qualy #6 - What are the best lab tests to request specifically for longevity9mins
Aug12#66 - Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?147mins
Aug6Qualy #1 - What are Peter's thoughts on alcohol consumption and health?11mins
Aug5#65 - Rick Doblin, Ph.D.: MDMA— the creation, scheduling, toxicity, therapeutic use, and changing public opinion of what is possibly the single most important synthetic molecule ever created by our species180mins
Jul29#64 - Zol Kryger, M.D.: Navigating the sometimes shady world of plastic surgery—understanding potential complications of common procedures and how to reduce your risk by choosing the right doctor and asking the right questions133mins
Jul22#63 - AMA #7: Exercise framework, deadlifting, lower back pain, blood pressure, nootropics, CGM, and more13mins
Jul15#62 - Keith Flaherty, M.D.: Deep dive into cancer—History of oncology, novel approaches to treatment, and the exciting and hopeful future177mins
Jul8#61 - Rajpaul Attariwala, M.D., Ph.D.: Cancer screening with full-body MRI scans and a seminar on the field of radiology133mins
Jul2The one-year anniversary episode with Olivia Attia: Reflecting on the past year and looking forward to exciting times ahead16mins
Jul1#60 - Annie Duke, decision strategist: Poker as a model system for life—how to improve decision making, use frameworks for learning, and apply ‘backcasting’ to boost your odds for future success155mins
Jun24#59 - Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness162mins
Jun17#58 – AMA with sleep expert, Matthew Walker, Ph.D.: Strategies for sleeping more, sleeping better, and avoiding things that are disrupting sleep29mins
Jun10#57 – Rick Rubin, legendary music producer: collaborating with sensitive psyche of greatest living musicians, and his personal story of weight loss and spiritual quest183mins
Jun3#56 - Jocko Willink, retired Navy SEAL, Part II of II: Sleep, fasting, raising kids, discipline, taking ownership, and the impact of war91mins
May27#55 - Jocko Willink, retired Navy SEAL, Part I of II: objective, strategy & tactics, leadership, protocols, dealing with death, and applying the many lessons learned from war159mins
May20#54 – Kevin Sayer, CEO of Dexcom: Continuous glucose monitors – impact of food, sleep, and stress on glucose, the unmatched power of CGM to drive behavioral change, and the exciting future of CGM104mins
May13#53 - AMA #6: Fasting framework, vitamin supplementation, antioxidants, time management, problem-solving, and more12mins
May6#52 - Ethan Weiss, M.D.: A masterclass in cardiovascular disease and growth hormone - two topics that are surprising interrelated174mins
May1The Ayrton Senna Episode (re-release): Celebrating the greatest driver in Formula 1 history and the cautionary tales of driven individuals63mins
Apr29#51 - Robert Sapolsky, Ph.D.: The pervasive effect of stress - is it killing you?138mins
Apr22#50 - AMA #5: calcium scores, centenarian olympics, exercise, muscle glycogen, keto, and more11mins
Apr15#49 – Matthew Walker, Ph.D., on sleep – Part III of III: The penetrating effects of poor sleep from metabolism to performance to genetics, and the impact of caffeine, alcohol, THC, and CBD on sleep121mins
Apr8#48 – Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer, sexual function, and the causes of sleep disruption (and tips to correct it)124mins
Apr1#47 – Matthew Walker, Ph.D., on sleep – Part I of III: Dangers of poor sleep, Alzheimer's risk, mental health, memory consolidation, and more.103mins
Mar25#46 - Chris Masterjohn, Ph.D.: Navigating the many pathways to health and disease - NAD and sirtuins, methylation, MTHFR and COMT, choline deficiency and NAFLD, TMAO, creatine, and more171mins
Mar18#45 - AMA #4: sleep, jet lag protocol, autophagy, metformin, and more12mins
Mar11#44 - Jeremy Schaap, ESPN journalist: upsets, doping, triumphs, and the importance of sports101mins
Mar4#43 - Alan Bauman, M.D.: The science of male and female hair restoration - how to protect, enhance, and restore the appearance and health of the hair and scalp115mins
Feb25#42 - Avrum Bluming, M.D., and Carol Tavris, Ph.D.: Controversial topic affecting all women—the role of hormone replacement therapy through menopause and beyond—the compelling case for long-term HRT and dispelling the myth that it causes breast cancer140mins
Feb18#41 - Jake Kushner, M.D.: How to thrive with type 1 diabetes and how everyone can benefit from the valuable insights127mins
Feb11#40 - Tom Catena, M.D.: The world’s most important doctor – to nearly a million patients – saving countless lives in the war-torn and remote villages of Sudan161mins
Feb4#39 - Ted Schaeffer, M.D., Ph.D.: How to catch, treat, and survive prostate cancer151mins
Jan28#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer’s disease treatment and prevention – is AD actually a vascular and metabolic disease?151mins
Jan21#37 - Zubin Damania, M.D.: Revolutionizing healthcare one hilariously inspiring video at a time171mins
Jan14#36 - Eric Chehab, M.D.: Extending healthspan and preserving quality of life158mins
Jan7#35 - Nir Barzilai, M.D.: How to tame aging167mins
Dec20#34 - Sam Harris, Ph.D.: The transformative power of mindfulness163mins
Dec17#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin140mins
Dec10#32 - Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine, and the writing process65mins
Dec3#31 - Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease142mins
Nov26#30 - Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?168mins
Nov19#29 - Apolo Anton Ohno: 8-time Olympic medalist – extreme training, discipline, pursuing perfection, and responding to adversity218mins
Nov12#28 - Mark and Chris Bell: steroids, powerlifting, addiction, diet, training, helping others, documentaries, and living your best life131mins
Nov5#27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging101mins
Oct29#26 - AMA #3: supplements, women’s health, patient care, and more128mins
Oct22#25 - Scott Harrison: transformation, finding meaning, and taking on the global water crisis138mins
Oct19#24 - Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more89mins
Oct18#23 - Tom Dayspring, M.D., FACP, FNLA – Part IV of V: Statins, ezetimibe, PCSK9 inhibitors, niacin, cholesterol and the brain120mins
Oct17#22 - Tom Dayspring, M.D., FACP, FNLA – Part III of V: HDL, reverse cholesterol transport, CETP inhibitors, and apolipoproteins64mins
Oct16#21 - Tom Dayspring, M.D., FACP, FNLA – Part II of V: Lipid metrics, lipid measurements, and cholesterol regulation86mins
Oct15#20 - Thomas Dayspring, M.D., FACP, FNLA – Part I of V: an introduction to lipidology74mins
Oct8#19 - Dave Feldman: stress testing the lipid energy model190mins
Oct1#18 - Richard Isaacson, M.D.: Alzheimer’s prevention144mins
Sep24#17 - Mike Trevino: life-lessons from ultra-endurance, mindset, hard work, and removing limitations116mins
Sep20#16 - Formula 1 (with Paul Conti): the best drivers, Ayrton Senna, and the cautionary tales of driven individuals63mins
Sep17#15 - Paul Conti, M.D.: trauma, suicide, community, and self-compassion129mins
Sep10#14 - Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system83mins
Sep3#13 - Brett Kotlus, M.D.: How to look younger while you live longer108mins
Aug27#12 - Corey McCarthy: Overcoming trauma, dealing with shame, finding meaning, changing the self-narrative, redemption, and the importance of gratitude147mins
Aug23#11 - AMA #2: the Nothingburger — results from Peter’s week-long fast between two weeks of nutritional ketosis — and answering questions on all things fasting110mins
Aug20#10 - Matt Kaeberlein, Ph.D.: rapamycin and dogs — man’s best friends? — living longer, healthier lives and turning back the clock on aging, and age-related diseases92mins
Aug13#09 - David Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity?71mins
Aug6#08 - Tom Bilyeu: nutrition, fasting, meditation, mindset, immortality, and the secret formula of fulfillment98mins
Jul30#07 - Deep Dive: Lp(a) — what every doctor, and the 10-20% of the population at risk, needs to know76mins
Jul23#06 - D.A. Wallach: music, medicine, cancer screening, and disruptive technologies139mins
Jul16#05 - Dom D’Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer163mins
Jul9#04 - AMA #1: alcohol, best lab tests, wearables, finding the right doc, racing, and more133mins
Jul2#03 - Ron Krauss, M.D.: a deep dive into heart disease116mins
Jul2#02 - Rhonda Patrick, Ph.D.: the performance and longevity paradox of IGF-1, ketogenic diets and genetics, the health benefits of sauna, NAD+, and more109mins
Jul2#01 - Tim Ferriss: depression, psychedelics, and emotional resilience156mins- Jun19#00 - Sneak Peek: The Peter Attia Drive6mins
