Podcst

The evolutionary science behind why you can’t lose weight and how to avoid 5 modern food mistakes | Prof Daniel Lieberman

ZOE Science & Nutrition

ZOE

August 6, 2026

Show Notes

Why can’t you lose weight, and why do modern diets fail?

Today, Harvard professor Daniel Lieberman explains how evolution shapes hunger, body fat, food cravings, and modern food mistakes. You will learn why eating well can feel so hard in today’s food world.

Using themes from Daniel’s new book, Fed Up: What Evolution Reveals about Food, Diet and Eating Well, we explore how our modern food environment explains weight gain, failed diets, and confusion about what to eat. We discuss calorie counting, ultra-processed food, hunger, and why there may be no single “best” diet for everyone.

By the end of the episode, you’ll have some simple ways to make better food choices and will know how to make healthy choices easier.

If your body evolved for a world where food was scarce, what does that mean for how you eat today?

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Timecodes

Intro

The 3 reasons evolution changes what you eat

Why supermarkets make healthy eating harder

Why sugar and fat are so hard to resist

Are humans really fatter than hippos?

Why your brain burns so much energy

Why humans evolved to hold onto fat

The 3 hidden costs behind body fat

How cooking changed the human body

Why raw food may not be natural for humans

Did farming make humans less healthy?

How processed food transformed what we eat

Why modern food triggers ancient cravings

What the paleo diet gets wrong

Why there is no real paleo diet

Why calorie counting can mislead you

Why hunger beats willpower

Why weight loss often comes back

What you need to know before buying food

Why no diet is truly optimal

What the healthiest diets have in common

Are your genes really making you gain weight?

The simple shopping trick Daniel uses

Why the 8-hour sleep rule is wrong

Why stress makes you crave comfort food

Why simple diet rules fail


📚Books by our ZOE Scientists

The Food For Life Cookbook

Every Body Should Know This by Dr Federica Amati

The Appetite Reset by Dr Federica Amati

Food For Life by Prof. Tim Spector

Ferment by Prof. Tim Spector

Good Mood Food (preorder) by Prof. Tim Spector

Free resources from ZOE

TheSmart Snacking Guide: How to feed your gut, fuel your day, and snack without guilt

The Hormone Harmony Guide: Tuning Your Body’s Internal Orchestra  

Eating for Better Brain Health: Your brain-gut blueprint

Howto eat in 2026- Discover ZOE’s 8 nutrition principles for long-term health

Live Healthier: Top 10 Tips From ZOE Science & Nutrition

Gut Guide - For a Healthier Microbiome in Weeks 

Better Breakfast Guide


Mentioned in today's episode

Fed Up: What Evolution Reveals about Food, Diet and Eating Well by Daniel Lieberman

Comparingdietary variation between tropical hunter-gatherer groups to the Paleo Diet, The American Journal of Clinical Nutrition (2023)

Thecarbohydrate-insulin model: a physiological perspective on the obesity pandemic, The American Journal of Clinical Nutrition (2021)

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Episode transcripts are available here.


The evolutionary science behind why you can’t lose weight and how to avoid 5 modern food mistakes | Prof Daniel Lieberman — Podcst