#30 - Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?
from The Peter Attia Drive
by Peter Attia, MD
Published: Mon Nov 26 2018
Show Notes
In this episode, Thomas Seyfried, a cancer researcher and professor of biology at Boston College, discusses a controversial view of cancer as a mitochondrial metabolic disease. Many topics related to the causes, treatments, and prevention of cancer are covered in this in-depth conversation.
We discuss:
- How Tom got interested in cancer research [9:00];
- Calorie-restricted ketogenic diets, fasting, and epileptic seizures [];
- Otto Warburg and the Warburg effect [];
- Germline mutations, somatic mutations, and no mutations [];
- Mitochondrial substrate level phosphorylation: Warburg's missing link [];
- What is the structural defect in the mitochondria in cancer? [];
- Peter's near-death experience with the insulin suppression test while in ketosis [];
- Insulin potentiation therapy and glutamine inhibition [];
- The macrophage fusion-hybrid theory of metastasis [];
- How are cancer cells growth dysregulated without a mutation? [];
- What is the dream clinical trial to test the hypothesis that we can reduce the death rates of cancer by 50%? [];
- How can the hypothesis be tested rigorously that structural abnormalities in the mitochondria impair respiration and lead to compensatory fermentation? [];
- Case studies of GBM survivors [];and
- More.
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