#02 - Rhonda Patrick, Ph.D.: the performance and longevity paradox of IGF-1, ketogenic diets and genetics, the health benefits of sauna, NAD+, and more

Rhonda and I go on a Nerd Safari into the jungle of health, nutrition, fitness, performance, and longevity. We visit IGF-1 and whether there’s a tradeoff of having high or low levels. We discuss the PPARs (receptor proteins) and genetic polymorphisms. Does Rhonda think there’s any benefit in a NAD+ booster for health and longevity? Can saunas lower the risk of heart disease, dementia, and all-cause mortality?

Rhonda is a wealth of knowledge on so many topics and was the perfect companion to dig into so many fun topics in this episode. She puts a ton of thought into her research and it really shows in this conversation.

We discuss:

• What Rhonda believes differently today than she did a few years ago [5:40];
• The paradox of GH/IGF-1 in performance and longevity [21:00];
• The role of PPAR in fat metabolism and ketogenic diets [23:00];
• The possible genetic explanations for why some patients don’t respond well to a ketogenic diet [31:00];
• The health benefits of heat and cold exposure [1:12:30];
• NAD+ [1:32:45];
• And more.

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