
Essentials: How to Control Your Sense of Pain & Pleasure
from Huberman Lab
by Scicomm Media
Published: Thu Jun 19 2025
Show Notes
In this Huberman Lab Essentials episode, I explore the sensations of pain and pleasure, explaining how they are sensed in the body and interpreted by the brain as well as methods to control their intensity.
I discuss both the hardwired mechanisms and subjective factors that shape an individual’s perception of pain and pleasure. I also explain why pain thresholds vary from person to person and discuss various treatments for pain management such as acupuncture and supplements. Finally, I explain the role of key neurochemicals like dopamine and serotonin in mediating our experience of pain and pleasure.
Read the episode show notes at hubermanlab.com.
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Timestamps
Pain & Pleasure
Skin, Appetitive vs Aversive Behaviors
Skin, Neurons & Brain
Brain Interpretation, Homunculus, Two-Point Discrimination Test
Pain & Pleasure, Subjective Interpretation
Sponsor: AG1
Tool: Pain & Expectation
Pain Threshold
Heat & Cold, Tool: Moving into Cold or Hot Environments
Subjective Pain, Psychosomatic, Fibromyalgia, Whole Body Pain, Acetyl-L-carnitine
Acupuncture, Electroacupuncture, Pain Management
Sponsors: LMNT & Eight Sleep
Red Heads & Pain Threshold, Endorphins
Improving Pain Threshold, Dopamine
Pleasure, Dopamine, Serotonin; Depression, Anti-depressants
Pleasure & Pain Balance, Dopamine, Addiction
Recap & Key Takeaways
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