The Science & Treatment of Bipolar Disorder
from Huberman Lab
by Scicomm Media
Published: Mon Jul 25 2022
Show Notes
In this episode, I explain the biology, symptoms, causes and types of bipolar disorder (sometimes called bipolar depression). I discuss neuroplasticity and how the brain normally regulates mood, energy, and perceptions; then, I contrast that with the biology of bipolar disorder, which is characterized by extremes of energy and mood, e.g., mania and depression. I outline the mechanisms through which bipolar disorder manifests in the brain, including deficits of interoception and reduced connections between the parietal and limbic systems. I also outline how treatment options (such as lithium) work in part through homeostatic plasticity.’ I discuss not only lithium but also the treatment of bipolar with ketamine, different talk therapies, electroconvulsive therapy, transcranial magnetic stimulation, and nutraceuticals, including Omega-3 and Inositol supplementation. This episode should interest anyone who has or knows someone with bipolar disorder and, more broadly, those interested in how the brain works to create a balance between thoughts, energy levels, focus, and mood.
For the full show notes, visit hubermanlab.com.
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Timestamps
(00:00:00)Bipolar Disorder
()Tool: Appetite Suppression & GLP-1, Parallel Pathways, Yerba Mate
(00:9:19) Sponsors: AG1, LMNT
()Prevalence & Severity of Bipolar Disorder
()Bipolar Disorder I, Diagnostic Criteria of Mania
()Bipolar Disorder II, Individual Variability
()Bipolar I vs. Bipolar II: Manic, Depressive & Symptom-Free States
()Consequences of Bipolar Disorder, Heritability
()Bipolar Disorder vs. Borderline Personality Disorder
()Mania & Depression, Negative Impacts
()History of Lithium Treatment
()Lithium Treatment & Side-Effects
()Effects of Lithium: BDNF, Anti-inflammatory & Neuroprotection
()Neural Circuits of Bipolar Disorder, Interoception, Hyper- vs. Hypoactivity
()Neural States & Mania, Parietal Lobe & Limbic System
()Homeostatic Plasticity, Synaptic Scaling, Lithium & Ketamine
()Talk Therapies: Cognitive Behavioral Therapy, Family-Focused Therapy, Interpersonal & Social Rhythm Therapy
()Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (rTMS)
()Psylocibin, Cannabis
()Lifestyle Support, Supplements: Inositol & Omega-3 Fatty Acids
()Omega-3s, Membrane Fluidity & Neuroplasticity
()Mania, Creativity & Occupations
()Bipolar Disorder: Diagnosis, Neural Circuits & Treatment
()Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac