Essentials: Understanding & Conquering Depression

from Huberman Lab

by Scicomm Media

Published: Thu Jul 03 2025

Show Notes

In this Huberman Lab Essentials episode, I explore major depression, including its underlying biology and discuss science-based approaches to alleviate symptoms and improve mood.

I describe the wide-ranging symptoms of depression and explain how key neurotransmitters, hormones, stress, genetics and inflammation contribute to its development and persistence. I also cover treatment options, from traditional classes of antidepressant medications to emerging therapies such as ketamine and psilocybin. Finally, I highlight lifestyle-based tools, including exercise, supplementation and dietary strategies that can help manage depressive symptoms and promote mental well-being.

Read the episode show notes at hubermanlab.com.

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Timestamps

Major Depression

Depression Symptoms

Sponsor: BetterHelp

Pharmaceuticals for Depression, SSRIs; Norepinephrine, Dopamine & Serotonin

Thyroid Hormone, Cortisol, Stress & Depression, Menstrual Cycle, Genetics

Sponsor: AG1